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Peak is now available in several 'weights' and with differing bundled content. Peak Pro XT 6 packs the biggest punch: as well as Peak Pro 6 itself, you get BIAS's SoundSoap 2 and SoundSoap Pro noise-reduction tools, the Reveal analysis tools, PitchCraft pitch correction, Repli-Q 'fingerprint' equaliser, the SuperFreq paragraphic EQ and the Sqweez three- and five-band compressor/limiters. Both the standard Peak Pro 6 version and Peak Pro XT 6 also come with SoundSoap LE, Reveal LE, WireTap Pro, SFX Machine LT and a one-year membership to Broadjam.com, plus a new selection of sound effects and other audio content from Hollywood Edge, Sound Ideas, Power FX and AMG. The more affordable Peak LE, meanwhile, dispenses with some of the more advanced Peak Pro features, but is still very powerful. A table outlining the full differences between the three versions is available at www.bias-inc.com/products/peakFeatures/index-verbose.php. This review covers the top-flight Peak Pro XT 6 package: for more on the bundled plug-ins, see the SOS reviews of BIAS's Master Perfection Suite (July 2008: /sos/jun08/articles/biasmps.htm) and SoundSoap Pro (February 2005: /sos/feb05/articles/soundsoap.htm). The LE versions are identical to the stand-alone versions, except that they can only be used within Peak and not within other DAW applications.
Effect of varying scan duration on tumor SUVmax (A), SUVpeak (B), and SUVmean (C). Each colored data series represents normalized SUVs for particular patient. Normalization is relative to corresponding SUV measurement obtained from low-noise 15-min image. Solid lines join averages for all patients. Increasing positive bias is seen for SUVmax and, to lesser extent, SUVpeak as scan duration decreases (image statistical quality degrades).
A within-subject, randomized, placebo-controlled, double-dummy, double-blind clinical study compared the acute therapeutic analgesic potential of two potencies of smoked cannabis (1.98% and 3.56% THC, 800 mg cigarettes with 16 mg and 28 mg THC respectively) to two doses of dronabinol (10 and 20 mg) in response to an experimental pain stimulus (i.e. cold pressor test) that has predictive validity for pharmacotherapies used to treat chronic painReference 831. The study found that both cannabis and dronabinol produced analgesic effects in this model and there were also no significant differences between dronabinol and smoked cannabis in measures of pain sensitivity (i.e. latency to first feel pain). However, in terms of pain tolerance, low potency smoked cannabis (1.98% THC) and both low and high dronabinol doses increased the latency to report pain relative to placebo. Both strengths of cannabis and the high dronabinol dose (20 mg) decreased subjective ratings of pain intensity and bothersomeness of the cold-pressor test compared to placebo although these decreases were greater after cannabis relative to dronabinol. Both cannabis strengths and the high dronabinol dose increased subjective ratings of "high" and "good drug effect" relative to placebo, and both cannabis strengths (but not the low dronabinol dose) increased ratings of "stimulated" relative to placebo. Lastly, both strengths of cannabis and the high dronabinol dose increased ratings of "marijuana strength", "liking", and "willingness to take again". There did not appear to be any sex-dependent differences in terms of baseline pain measures, analgesic, subjective, or physiological effects across all cannabis or dronabinol conditions. Overall, dronabinol decreased pain sensitivity and increased pain tolerance and these effects peaked later and lasted longer compared to smoked cannabis, while smoked cannabis produced a greater attenuation of subjective ratings of pain intensity compared to dronabinol. Peak subjective ratings of dronabinol's drug effects occurred significantly earlier than decreases in pain sensitivity and increases in pain tolerance (60 min vs. 4 h). Limitations of this study include a potentially biased study population that consisted of daily cannabis users as well as the experimental nature of the pain stimulus in subjects not normally experiencing pain. 2b1af7f3a8
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