Skep 82 Ii 2004 Pdf 65 |WORK|

4. A 50-year-old vaccinee who received 3 doses of PCV7 in 2007-2009 would have 97% probability of protecting themselves (and their babies) from pneumococcal disease caused by PCV7 vaccine serotypes. In those over 65, the corresponding probability would be only 58%.

In the US, the PCV7 vaccine was not widely implemented, with only six PCV7-serotypes included in the vaccine and only ~25% of isolates in the pre-vaccine era were PCV7-serotypes. In Quebec, PCV7 was implemented in 2007 with 3 doses recommended in young adults aged 18-64 years and one dose recommended for those aged 65 years and older. PCV7 coverage in the three studies reviewed was approximately 80%-90%.

In summary, PCV7 programs resulted in significant reductions in VT CAP incidence among older adults in all three regions, with the greatest absolute reductions in Canada. In Canada, PCV7 implementation was most notable in the cohort aged 50-64, where the 2008-2010 trend line closely followed that of the pre-PCV7 period and, in Canada and the UK, the largest absolute reductions were seen in the older adult population aged >65, while in the US and Quebec, the largest absolute reductions were seen in the middle-aged cohort aged 50-64.

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